Questionable along with Bosa, Greenlaw and Guerendo is defensive tackle Khalil Davis, who has a knee injury. Linebackers Demetrius Flannigan-Fowles (knee) and Dee Winters (ankle), defensive ends Yetur Gross-Matos (knee) and Sam Okuayinonu (wrist) and safety Talanoa Hufanga (wrist) are all cleared to go after appearing on the injury list.

Talanoa Hufanga and Dre Greenlaw are making their way back onto the field but their energy already has been making a difference on the 49ers practice

While the 49ers will be without left tackle Trent Williams for a fourth straight game on Thursday night, there's at least a chance for three other key players to be available against the Rams.