San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Christian McCaffrey reflected on his 2024 NFL season that fell short of expectations with a ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

San Francisco 49ers tight end George Kittle did not get the ball very much in his team's loss to the Buffalo Bills on Sunday ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the Bills, the conditions were ...

The Miami Dolphins' Week 16 matchup against the San Francisco 49ers at Hard Rock Stadium is losing luster by the minute. What ...

Fullback Kyle Juszczyk lost a fumble inside Buffalo’s 5-yard line when the 49ers were threatening to score. In totality, it ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

There's even a chance Guerendo, who pulled his hamstring on the first day of training camp and missed the first two preseason ...