Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly ...

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

Sondra Williams, the wife of San Francisco 49ers tackle Trent Williams, said on social media that their son, Trenton, was ...

The 49ers brass — Kyle Shanahan, John Lynch, and CEO Jed York chief among them — have not wavered on their commitment to ...

Running back Christian McCaffrey has a PCL injury in his right knee and it's a six-week recovery, 49ers coach Kyle Shanahan ...