The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

The 49ers brass — Kyle Shanahan, John Lynch, and CEO Jed York chief among them — have not wavered on their commitment to ...

The 49ers opened the practice window for safety Talanoa Hufanga, who has missed the last seven games with a wrist injury.

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

Could the San Francisco 49ers trade head coach Kyle Shanahan? One insider thinks the Chicago Bears should try to make the ...

Mia DeCamilla, an eight-year-old San Francisco 49ers fan and cancer survivor, was attending her first NFL game on Sunday ...

The San Francisco 49ers are undeniably suffering from the Super Bowl hangover. While it took until the second half of last ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...

After Trent Williams and wife Sondra shared the devastating loss of their son Trenton O'Brien Williams Jr. from a stillbirth, ...

The Buffalo Bills are making a kind gesture to the young fan who was pushed down the stairs during last Sunday night's game ...

The physical brand of football the 49ers play is something Thomas Brown wants the Bears to emulate but the question is ...

The Series: The 70th game between the teams. The 49ers lead 35-33-1. San Francisco is 22-14 at home in the series. The Bears ...