This has led to a profound resource drain to the 49ers. They kept up their turn-and-burn roster approach of letting guys ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

Temperatures reached the 20s Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

RB Christian McCaffrey, playing in just his fourth game since returning from Achilles tendinitis, suffered a PCL injury ...

Ahead of their game against the Buffalo Bills, it’s time to release our San Francisco 49ers Week 13 predictions.

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

Snow flew like confetti in celebration from the packed stands as the Bills (10-2) scored on four of five possessions spanning ...

The San Francisco 49ers’ Sunday Night Football showdown with the Buffalo Bills turned into a nightmare, and fans are not holding back. A 35-10 drubbing left the 49ers reeling and X ablaze with calls ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

The San Francisco 49ers' visit to Buffalo could be more painful than expected for Kyle Shanahan following the loss to the ...

See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.