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San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers linebacker Fred Warner recently revealed that he has been playing through a bone fracture in his ankle, ...

On Tuesday morning's PFT Live, I threw out the idea of the Bears ditching the normal approach to hiring head coaches and calling the 49ers to see whether they'd be willing to trade Kyle Shanahan.

San Francisco 49ers DB Deommodore Lenoir is showcasing his support for athletes with Down syndrome through custom-designed ...

Should Guerendo start as expected on Sunday, it will be just his second start as a running back since he was in the fourth grade.

Join Packers Head Coach Matt LaFleur and analyst Larry McCarren as they recap the Packers' Week 13 win over Miami and preview ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) missed his second contest in a row due to hip and oblique injuries.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

The 49ers' quarterback room simply isn't good enough. Last season, they had Brock Purdy AND Sam Darnold. That was a good ...

Twenty-four hours into his newest promotion, Chicago Bears interim head coach Thomas Brown talked about weight loss, chasing excellence — not perfection — and if it all ...