The San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in Santa Clara, California, on Thursday, December 12 ...

Running back Isaac Guerendo is officially active for the the 49ers' pivotal "Thursday Night Football" game against the Los Angeles Rams despite dealing with a foot injury on a short week.

The Buffalo Bills were impressive in their week 13 destruction of a desperate and depleted San Francisco 49ers team, blowing ...

And we are off for Week 15 of NFL football, this time, as will probably be the case plenty of times for the remainder of the ...

Niners coach Kyle Shanahan uses 21 personnel (two backs, one tight end, two wideouts) on a league-high 37.9% of snaps, ...

The Bills (10-2) took a 35-10 win over the Niners (5-7). In what ended up as a winter wonderland in western New York, Buffalo ...

Micah Roberts, on a 25-6 run on San Francisco 49ers picks, has revealed his Sunday Night Football expert picks for San ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

ORCHARD PARK, N.Y. (WROC) — In wintry conditions at Highmark Stadium, the Bills took down the 49ers 35-10 to win their fifth ...

San Francisco 49ers QB Brock Purdy (shoulder) is questionable to play in Sunday night's showdown against the Buffalo Bills, ...

San Francisco 49ers linebacker De'Vondre Campbell threatened Bills receiver Mack Hollins for pulling on his dreadlocks during ...

Lake-effect snow has been hitting Buffalo throughout the holiday weekend with is expected to continue off and on through ...