Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San Francisco lost 38–10. The 25-year-old was limited in practice this week on Wednesday and Thursday, and was a full participant on Friday. He's officially listed as questionable for Sunday.

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after recovering from a shoulder

As for Purdy’s supporting cast, it will be without some key players. The 49ers will be missing the left side of their starting offensive line as tackle Trent Williams (ankle) and guard Aaron Banks (concussion) are out and will not make the trip.