While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...

The Pittsburgh Steelers and Cleveland Browns had one of the most picturesque games in NFL history last Thursday night when ...

San Francisco 49ers head coach Kyle Shanahan told reporters that star quarterback Brock Purdy will practice with the team ...

Buffalo Bills head coach Sean McDermott offered an update on linebacker Matt Milano's injury status upon the team's return from its bye week.

The San Francisco 49ers have officially opened linebacker Dre Greenlaw's 21-day practice window, giving the team until ...

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday's loss at ...

There is a High Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the San Francisco 49ers ...

There was a time when most football fans disliked seeing the Detroit Lions on Thanksgiving. The Lions were often bad and the ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau Field ...

The Cowboys are still the centerpiece at the NFL Thanksgiving table, but this year's showdown vs. the Giants could leave ...