The Bills and 49ers play Sunday, Dec. 1 at 8:20 p.m. at Highmark Stadium in Orchard Park. The game will be broadcast on local NBC affiliates, including WHEC Channel 10 in Rochester. The game will be ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three questions heading into the game.

Buffalo Bills team reporter Maddy Glab joins 1st & 10 to breakdown the 49ers-Bills matchup, discuss what to expect on "SNF" ...

Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

Quarterback Tua Tagovailoa hopes to continue his hot streak in the cold when he and the Miami Dolphins visit Lambeau<a class= ...

Watch eight NFL games live on Sky Sports in Week 13, including the Kansas City Chiefs against the Las Vegas Raiders at 8pm on ...

Travis Hunter is No. 1 overall, but where does his teammate Shedeur Sanders go? Plus, Georgia dominates the back end of the ...

San Francisco 49ers head coach Kyle Shanahan provided updates on his roster Wednesday ahead of the team's first full practice ...

And as the Bills prepare for a Sunday night game against the San Francisco 49ers, those temperatures are sure to be low and ...

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday’s loss at Green Bay ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.